Across TCGA patient cohorts, COLQ mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COLQ-associated genes across cancer lineages are Notch1, N-Ras, and 4E-BP1. Each is linked with COLQ in more than 2 cancer types. Because this analysis shows association rather than direction, both COLQ-to-partner and partner-to-COLQ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLQ→partner) and Y-score (partner→COLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.166	+1.916	<.001	.009	3	3
UCEC	N-Ras →	-0.105	-1.349	.012	.037	3	2
UCEC	4E-BP1 →	+0.331	+2.730	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.108	-2.195	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.223	-1.662	.011	.011	3	1
UCEC	eIF4E →	+0.180	+3.335	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

COLQ survival (RNA) · tumor vs normal (RNA) · all COLQ data types