Across TCGA cell cohorts, COLQ mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COLQ-associated genes across cancer lineages are SPATA19, LCE1E, and TMEM72. Each is linked with COLQ in more than 1 cancer types. Because this analysis shows association rather than direction, both COLQ-to-partner and partner-to-COLQ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLQ→partner) and Y-score (partner→COLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA19 →	+0.011	+3.984	<.001	.006	3	1
BLOOD_Leukemia	LCE1E →	+0.343	+2.774	.003	.006	3	1
BLOOD_Leukemia	TMEM72 →	+1.035	+3.295	<.001	.009	3	1
BLOOD_Leukemia	TMEM244 →	+0.203	+2.966	.001	.005	3	1
BLOOD_Leukemia	SLC5A8 →	+0.069	+3.464	<.001	.003	3	1
BLOOD_Leukemia	DAZL →	+0.126	+4.493	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

COLQ survival (RNA) · tumor vs normal (RNA) · all COLQ data types