COL9A2

Across TCGA patient cohorts, COL9A2 mutation is significantly associated with the RNA expression of many other genes, with 2,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL9A2-associated genes across cancer lineages are LRRC59, CKS2, and C1orf109. Each is linked with COL9A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL9A2-to-partner and partner-to-COL9A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC59 grouped by COL9A2-low versus COL9A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL9A2→partner) and Y-score (partner→COL9A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC59 →	+0.426	+1.950	.003	.008	3	3
UCEC	CKS2 →	+0.556	+2.526	.001	.001	3	3
SKCM	C1orf109 →	+0.525	+2.378	.004	.002	3	3
SKCM	EMC1 →	+0.466	+2.845	.008	.001	3	3
SKCM	TIMM17A →	+0.463	+2.751	.006	.002	3	3
SKCM	MRPS18C →	+0.338	+2.751	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,215 associations by consensus.

LRRC59 by COL9A2 expression — UCEC

Explore this box plot interactively →