COL9A1

Across TCGA patient cohorts, COL9A1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL9A1-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and PCNA. Each is linked with COL9A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL9A1-to-partner and partner-to-COL9A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by COL9A1-low versus COL9A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL9A1→partner) and Y-score (partner→COL9A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.140	-1.415	.003	.008	3	5
UCEC	MEK1 →	+0.418	+2.000	<.001	<.001	3	3
UCEC	PCNA →	+0.211	+2.058	<.001	<.001	3	3
UCEC	Tuberin →	+0.308	+2.000	<.001	.002	3	3
LUAD	FOXO3a_pS318_S321 →	-0.091	-3.153	.030	.018	3	2
LUAD	HER2_pY1248 →	-0.279	-1.874	.021	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

JNK_pT183_Y185 by COL9A1 expression — UCEC

Explore this box plot interactively →