COL8A2

Across TCGA patient cohorts, COL8A2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL8A2-associated genes across cancer lineages are Notch1, Rb_pS807_S811, and Beclin. Each is linked with COL8A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL8A2-to-partner and partner-to-COL8A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by COL8A2-low versus COL8A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL8A2→partner) and Y-score (partner→COL8A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.166	+2.817	.041	.036	3	1
UCEC	Rb_pS807_S811 →	-0.538	-3.000	.021	.037	3	1
UCEC	Beclin →	+0.112	+3.000	.039	.037	3	1
SKCM	Bcl-xL →	-0.292	-3.000	.004	.036	3	1
UCEC	Lck →	+0.402	+3.000	<.001	.037	1	2
UCEC	p62 Lck ligand →	+0.504	+3.009	.007	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by COL8A2 expression — UCEC

Explore this box plot interactively →