COL8A1

Across TCGA pan-cancer cohorts, COL8A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL8A1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL8A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL8A1 expression acts as an unfavorable survival marker.

PDAC, LSCC, and COAD are the cancer types where COL8A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.303	0.473	.004	41	view →
LSCC	DFS	Median	II,III,IV	0.491	0.863	.001	13	view →
COAD	DFS	Median	III,IV	0.826	1.000	.023	6	view →
GBM	OS	Quartile	All	0.738	0.966	.024	5	view →
CCRCC	DFS	Tertile	III,IV	0.078	0.740	.038	3	view →
HNSC	DFS	Median	IV	0.548	0.772	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL8A1–PDAC (DFS)

Open the PDAC breakdown →