COL8A1

Across TCGA patient cohorts, COL8A1 mutation is significantly associated with the RNA expression of many other genes, with 3,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL8A1-associated genes across cancer lineages are SRRD, RNF167, and CARS1. Each is linked with COL8A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL8A1-to-partner and partner-to-COL8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRRD grouped by COL8A1-low versus COL8A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL8A1→partner) and Y-score (partner→COL8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SRRD →	+0.359	+1.567	.002	.001	3	3
UCEC	RNF167 →	+0.374	+2.432	<.001	<.001	3	3
UCEC	CARS1 →	+0.423	+2.338	<.001	<.001	3	3
UCEC	DNAJC8 →	+0.428	+1.857	<.001	<.001	3	3
UCEC	RTF1 →	+0.446	+2.443	<.001	<.001	3	3
UCEC	RNF185 →	+0.362	+2.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,570 associations by consensus.

SRRD by COL8A1 expression — SKCM

Explore this box plot interactively →