COL8A1

Across TCGA patient cohorts, COL8A1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL8A1-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and Notch1. Each is linked with COL8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL8A1-to-partner and partner-to-COL8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by COL8A1-low versus COL8A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL8A1→partner) and Y-score (partner→COL8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.099	-1.668	.022	.021	3	2
UCEC	mTOR_pS2448 →	-0.117	-2.095	.023	.017	3	2
UCEC	Notch1 →	+0.165	+1.920	<.001	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.409	-1.415	.008	.043	3	2
SKCM	p90 RSK →	+0.192	+2.459	.008	.017	3	2
UCEC	PCNA →	+0.247	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FOXO3a_pS318_S321 by COL8A1 expression — UCEC

Explore this box plot interactively →