COL8A1

Across TCGA cell cohorts, COL8A1 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL8A1-associated genes across cancer lineages are ELOA3DP, DYDC1, and AADACL3. Each is linked with COL8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL8A1-to-partner and partner-to-COL8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by COL8A1-low versus COL8A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL8A1→partner) and Y-score (partner→COL8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.022	+2.688	<.001	.002	3	2
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	1
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
SKIN	ODF1 →	+0.016	+4.437	<.001	.004	3	1
SKIN	CHAT →	+0.024	+4.054	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

ELOA3DP by COL8A1 expression — LARGE_INTESTINE

Explore this box plot interactively →