COL7A1

Across TCGA pan-cancer cohorts, COL7A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL7A1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COL7A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COL7A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where COL7A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	1.000	0.498	.017	9	view →
PDAC	DFS	Quartile	All	0.302	0.521	.021	8	view →
HNSC	DFS	Tertile	II,III,IV	0.983	0.898	.043	4	view →
LSCC	DFS	Tertile	III,IV	0.916	0.473	.020	3	view →
UCEC	DFS	Quartile	All	0.707	0.921	.030	2	view →
GBM	DFS	Median	All	0.559	0.764	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL7A1–LUAD (DFS)

Open the LUAD breakdown →