COL7A1

Across TCGA patient cohorts, COL7A1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COL7A1-associated genes across cancer lineages are eIF4E, PCNA, and 4E-BP1. Each is linked with COL7A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL7A1-to-partner and partner-to-COL7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by COL7A1-low versus COL7A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL7A1→partner) and Y-score (partner→COL7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.234	+2.820	<.001	.001	3	7
COAD	PCNA →	+0.284	+2.820	<.001	.001	3	5
STAD	4E-BP1 →	+0.371	+2.906	.001	.001	3	5
BLCA	PRDX1 →	+0.248	+1.874	.001	.047	3	4
COAD	c-Kit →	-0.526	-1.678	.009	.020	3	4
STAD	Cyclin-B1 →	+0.478	+3.459	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

eIF4E by COL7A1 expression — COAD

Explore this box plot interactively →