Across TCGA patient cohorts, COL6A6 protein abundance is significantly associated with the RNA expression of many other genes, with 9,588 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COL6A6-associated genes across cancer lineages are CTSG, RHOJ, and ROBO4. Each is linked with COL6A6 in more than 5 cancer types. Because this analysis shows association rather than direction, both COL6A6-to-partner and partner-to-COL6A6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A6→partner) and Y-score (partner→COL6A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CTSG →	+1.414	+0.954	<.001	<.001	3	6
HNSC	RHOJ →	+0.558	+0.519	<.001	<.001	3	6
OV	ROBO4 →	+0.695	+0.701	<.001	.003	3	5
OV	MS4A4A →	+0.927	+0.530	.001	.007	3	5
HNSC	BIN2 →	+0.928	+0.588	<.001	<.001	3	5
LSCC	FHL5 →	+0.857	+0.551	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,588 associations by consensus.

Exploration

COL6A6 survival (RNA) · tumor vs normal (RNA) · all COL6A6 data types