Across TCGA patient cohorts, COL6A6 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A6-associated genes across cancer lineages are PAI-1, PCNA, and Caspase-7-cleavedD198. Each is linked with COL6A6 in more than 5 cancer types. Because this analysis shows association rather than direction, both COL6A6-to-partner and partner-to-COL6A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A6→partner) and Y-score (partner→COL6A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PAI-1 →	+0.634	+1.874	.002	.048	3	6
COAD	PCNA →	+0.236	+1.906	<.001	.013	3	5
COAD	Caspase-7-cleavedD198 →	+1.187	+2.281	<.001	<.001	3	5
COAD	RAD51 →	+0.109	+2.584	.011	<.001	3	5
UCEC	ATM →	-0.467	-1.509	<.001	<.001	3	5
LUSC	LKB1 →	+0.134	+3.459	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration

COL6A6 survival (RNA) · tumor vs normal (RNA) · all COL6A6 data types