Across TCGA cell cohorts, COL6A6 mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL6A6-associated genes across cancer lineages are OTC, MROH5, and OR5H6. Each is linked with COL6A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL6A6-to-partner and partner-to-COL6A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A6→partner) and Y-score (partner→COL6A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OTC →	+0.050	+2.622	<.001	<.001	3	3
BONE	MROH5 →	+0.005	+4.169	<.001	.008	3	2
SOFT_TISSUE	OR5H6 →	+0.016	+4.369	<.001	.008	3	2
LARGE_INTESTINE	NTN5 →	+0.286	+2.364	.004	<.001	3	2
BLOOD_Lymphoma	VMAC →	+0.502	+3.074	.005	.008	3	2
BLOOD_Lymphoma	BECN2 →	+0.114	+2.155	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

Exploration

COL6A6 survival (RNA) · tumor vs normal (RNA) · all COL6A6 data types