Across TCGA pan-cancer cohorts, COL6A4P2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of COL6A4P2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where COL6A4P2 RNA is repressed in tumor relative to normal tissue. In most cancer types COL6A4P2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.
KIRP, LUAD, and KICH are the cancer types where COL6A4P2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL6A4P2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.