COL6A3

Across TCGA patient cohorts, COL6A3 mutation is significantly associated with the RNA expression of many other genes, with 9,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A3-associated genes across cancer lineages are CHAF1A, UHRF1, and HELLS. Each is linked with COL6A3 in more than 7 cancer types. Because this analysis shows association rather than direction, both COL6A3-to-partner and partner-to-COL6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by COL6A3-low versus COL6A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A3→partner) and Y-score (partner→COL6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.663	+2.120	<.001	<.001	3	8
UCEC	UHRF1 →	+0.907	+1.986	<.001	<.001	3	7
LUAD	HELLS →	+0.530	+1.778	<.001	<.001	3	7
UCEC	PSMC3IP →	+0.585	+1.756	<.001	<.001	3	7
LUAD	NUSAP1 →	+0.696	+1.918	<.001	.008	3	7
LUAD	KIF11 →	+0.749	+1.766	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,622 associations by consensus.

CHAF1A by COL6A3 expression — UCEC

Explore this box plot interactively →