COL6A3

Across TCGA patient cohorts, COL6A3 mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A3-associated genes across cancer lineages are c-Kit, Cyclin-B1, and CDK1. Each is linked with COL6A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL6A3-to-partner and partner-to-COL6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by COL6A3-low versus COL6A3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A3→partner) and Y-score (partner→COL6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	c-Kit →	-0.486	-1.058	<.001	.029	3	5
LUAD	Cyclin-B1 →	+0.647	+3.321	<.001	.009	3	5
COAD	CDK1 →	+0.131	+1.664	.003	.002	3	5
UCEC	JNK_pT183_Y185 →	-0.135	-1.688	<.001	<.001	3	4
BLCA	Tuberin →	+0.289	+2.700	.008	.005	3	4
STAD	CD31 →	-0.113	-1.584	.026	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

c-Kit by COL6A3 expression — COAD

Explore this box plot interactively →