COL6A3

Across TCGA cell cohorts, COL6A3 mutation is significantly associated with the RNA expression of many other genes, with 795 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL6A3-associated genes across cancer lineages are PPAT, D2HGDH, and PPP2R5C. Each is linked with COL6A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL6A3-to-partner and partner-to-COL6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPAT grouped by COL6A3-low versus COL6A3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A3→partner) and Y-score (partner→COL6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPAT →	+0.493	+2.504	.002	<.001	3	3
LUNG_NSCLC_LUAD	D2HGDH →	-0.888	-3.584	<.001	<.001	3	3
BLOOD_Leukemia	PPP2R5C →	+0.821	+1.936	<.001	.004	3	3
LARGE_INTESTINE	CARD6 →	-0.587	-1.724	.002	.002	3	3
LARGE_INTESTINE	RAPGEF3 →	-0.937	-1.480	<.001	<.001	3	3
SOFT_TISSUE	HELT →	+0.392	+3.297	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 795 associations by consensus.

PPAT by COL6A3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →