COL5A3

Across TCGA pan-cancer cohorts, COL5A3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of COL5A3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where COL5A3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COL5A3 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where COL5A3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL5A3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+1.212	<.001	12	view →
COAD	Male	All	−1.300	<.001	11	view →
HNSC	All	II,III,IV	+0.294	.001	8	view →
LUAD	Female	All	−0.388	<.001	6	view →
PDAC	All	All	+0.504	.002	4	view →
OV	All	All	−1.217	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

COL5A3–CCRCC

Open the CCRCC breakdown →