Across TCGA pan-cancer cohorts, COL5A2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COL5A2 data layer compared with 23 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher COL5A2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COL5A2 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

KIRC, STAD, and UCEC are the cancer types where COL5A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.221	0.789	.016	30	view →
STAD	DFS	Median	II,III,IV	0.909	0.594	.029	11	view →
UCEC	DFS	Median	All	0.740	0.635	.041	8	view →
OV	DFS	Median	III,IV	0.130	0.534	<.001	6	view →
COAD	DFS	Median	All	0.912	0.773	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: COL5A2 tumor-vs-normal RNA expression · all COL5A2 data types