Across TCGA pan-cancer cohorts, COL5A2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COL5A2 data layer compared with 23 for mass-spec protein and 5 for mutation status.
The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL5A2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COL5A2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.
PDAC, COAD, and LSCC are the cancer types where COL5A2 mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.