Across TCGA cell cohorts, COL5A2 mutation is significantly associated with the RNA expression of many other genes, with 1,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL5A2-associated genes across cancer lineages are ZBBX, ORC2, and MED31. Each is linked with COL5A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL5A2-to-partner and partner-to-COL5A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A2→partner) and Y-score (partner→COL5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZBBX →	+0.518	+3.099	<.001	.003	3	3
LUNG_NSCLC_LUAD	ORC2 →	+0.324	+3.321	.009	.004	3	3
LARGE_INTESTINE	MED31 →	+0.628	+2.459	<.001	.006	3	3
LARGE_INTESTINE	TRAPPC13 →	+0.422	+1.949	.001	.002	3	3
LARGE_INTESTINE	S100PBP →	+0.697	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	TTC21B →	+0.542	+3.386	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

Exploration

COL5A2 survival (RNA) · tumor vs normal (RNA) · all COL5A2 data types