COL5A1

Across TCGA pan-cancer cohorts, COL5A1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COL5A1 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COL5A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL5A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where COL5A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.575	0.829	<.001	43	view →
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	36	view →
LUAD	OS	Median	All	0.744	0.930	.001	18	view →
GBM	DFS	Tertile	All	0.229	0.502	.001	16	view →
PDAC	DFS	Quartile	III,IV	0.212	0.884	.006	15	view →
COAD	DFS	Median	All	0.882	1.000	.016	6	view →
UCEC	DFS	Quartile	All	1.000	0.901	.036	4	view →
HNSC	DFS	Median	II,III,IV	0.976	0.916	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COL5A1–LSCC (DFS)

Open the LSCC breakdown →