COL5A1

Across TCGA pan-cancer cohorts, COL5A1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of COL5A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COL5A1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COL5A1 is over-expressed in tumor.

HNSC, COAD, and LSCC are the cancer types where COL5A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL5A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.176	<.001	11	view →
COAD	All	III,IV	+0.390	<.001	10	view →
LSCC	Female	II,III,IV	+1.051	<.001	9	view →
LUAD	Male	III,IV	+0.967	<.001	8	view →
PDAC	Male	All	+1.093	<.001	6	view →
CCRCC	All	IV	+0.953	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

COL5A1–HNSC

Open the HNSC breakdown →