COL5A1

Across TCGA patient cohorts, COL5A1 mutation is significantly associated with the RNA expression of many other genes, with 9,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL5A1-associated genes across cancer lineages are NCAPG, CDCA2, and CDKN3. Each is linked with COL5A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL5A1-to-partner and partner-to-COL5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by COL5A1-low versus COL5A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A1→partner) and Y-score (partner→COL5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCAPG →	+0.776	+2.441	<.001	.001	3	7
STAD	CDCA2 →	+0.827	+3.712	<.001	<.001	3	6
LUAD	CDKN3 →	+0.950	+3.807	<.001	<.001	3	6
LUAD	OIP5 →	+0.941	+3.830	<.001	<.001	3	6
LUAD	FOXM1 →	+1.025	+2.201	<.001	<.001	3	6
STAD	RAD51C →	+0.385	+2.515	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,721 associations by consensus.

NCAPG by COL5A1 expression — LUAD

Explore this box plot interactively →