COL5A1

Across TCGA patient cohorts, COL5A1 mutation is significantly associated with the total protein of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL5A1-associated genes across cancer lineages are PCNA, Bim, and Cyclin-B1. Each is linked with COL5A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL5A1-to-partner and partner-to-COL5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by COL5A1-low versus COL5A1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A1→partner) and Y-score (partner→COL5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.301	+3.459	.003	.004	3	5
STAD	Bim →	+0.305	+2.000	.001	.028	3	4
LUAD	Cyclin-B1 →	+0.687	+2.222	<.001	.010	3	4
BLCA	eEF2 →	+0.309	+3.017	.008	.017	3	4
LUSC	Cyclin-E2 →	+0.122	+2.124	.015	.010	3	4
UCEC	ATM →	-0.502	-1.618	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

PCNA by COL5A1 expression — STAD

Explore this box plot interactively →