COL5A1

Across TCGA cell cohorts, COL5A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,777 significant associations in total. CNS shows the largest number of these associations.

The most reproducible COL5A1-associated GO terms across cancer lineages are Negative regulation of endodermal cell differentiation, Collagen fibril organization, and Positive regulation of actin filament bundle assembly. Each is linked with COL5A1 in more than 16 cancer types. Because this analysis shows association rather than direction, both COL5A1-to-partner and partner-to-COL5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endodermal cell differentiation grouped by COL5A1-low versus COL5A1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A1→partner) and Y-score (partner→COL5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of endodermal cell differentiation →	+1.482	+3.280	<.001	<.001	3	17
LIVER	Collagen fibril organization →	+0.488	+7.476	<.001	<.001	3	15
BONE	Positive regulation of actin filament bundle assembly →	+0.211	+3.446	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction organization →	+0.156	+2.919	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate junction organization →	+0.190	+2.771	<.001	<.001	3	13
LIVER	Positive regulation of supramolecular fiber organization →	+0.093	+4.590	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,777 associations by consensus.

Negative regulation of endodermal cell differentiation by COL5A1 expression — OESOPHAGUS

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