COL5A1

Across TCGA cell cohorts, COL5A1 mutation is significantly associated with the RNA expression of many other genes, with 2,113 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL5A1-associated genes across cancer lineages are HAUS2, RAB3IP, and CHAC2. Each is linked with COL5A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL5A1-to-partner and partner-to-COL5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS2 grouped by COL5A1-low versus COL5A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A1→partner) and Y-score (partner→COL5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAUS2 →	+0.531	+2.584	<.001	.002	3	4
BLOOD_Leukemia	RAB3IP →	+0.968	+3.321	.003	.005	3	3
LARGE_INTESTINE	CHAC2 →	+0.783	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	COMMD8 →	+0.568	+3.257	<.001	.002	3	3
LARGE_INTESTINE	ALG6 →	+0.644	+3.299	<.001	<.001	3	3
SOFT_TISSUE	NLRP5 →	+0.107	+4.058	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,113 associations by consensus.

HAUS2 by COL5A1 expression — LARGE_INTESTINE

Explore this box plot interactively →