Across TCGA pan-cancer cohorts, COL5A1-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of COL5A1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where COL5A1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types COL5A1-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and CHOL are the cancer types where COL5A1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL5A1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.212	<.001	6	view →
UCEC	All	All	−0.276	.021	2	view →
CHOL	All	All	+0.228	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: COL5A1-AS1 RNA expression & survival · all COL5A1-AS1 data types