Across TCGA pan-cancer cohorts, COL4A5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COL4A5 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COL4A5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL4A5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where COL4A5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.339	0.949	.006	17	view →
CCRCC	OS	Tertile	All	0.937	0.704	.010	8	view →
HNSC	OS	Median	II,III,IV	0.934	0.789	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: COL4A5 tumor-vs-normal RNA expression · all COL4A5 data types