Across TCGA patient cohorts, COL4A5 mutation is significantly associated with the RNA expression of many other genes, with 7,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A5-associated genes across cancer lineages are KDELR1, C19orf57, and MEN1. Each is linked with COL4A5 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL4A5-to-partner and partner-to-COL4A5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A5→partner) and Y-score (partner→COL4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KDELR1 →	+0.263	+2.257	.004	.005	3	5
LUAD	C19orf57 →	+0.528	+1.898	<.001	.001	3	5
LUAD	MEN1 →	+0.420	+2.959	<.001	<.001	3	5
UCEC	CDKN3 →	+0.756	+1.818	<.001	<.001	3	5
UCEC	GTF2E2 →	+0.431	+1.977	<.001	<.001	3	5
COAD	KDSR →	+0.456	+2.625	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,367 associations by consensus.

Exploration

COL4A5 survival (RNA) · tumor vs normal (RNA) · all COL4A5 data types