Across TCGA patient cohorts, COL4A5 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A5-associated genes across cancer lineages are A-Raf_pS299, Cyclin-B1, and ASNS. Each is linked with COL4A5 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A5-to-partner and partner-to-COL4A5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A5→partner) and Y-score (partner→COL4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.117	-1.716	<.001	.003	3	4
UCEC	Cyclin-B1 →	+0.599	+1.584	<.001	<.001	3	4
STAD	ASNS →	+0.640	+3.000	.005	.036	3	3
STAD	4E-BP1 →	+0.522	+3.000	<.001	.036	2	4
UCEC	EGFR_pY1068 →	-0.213	-1.662	.001	.009	3	3
UCEC	MEK1 →	+0.462	+2.402	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

COL4A5 survival (RNA) · tumor vs normal (RNA) · all COL4A5 data types