Across TCGA cell cohorts, COL4A5 mutation is significantly associated with the RNA expression of many other genes, with 689 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A5-associated genes across cancer lineages are ETDB, ENPP5, and HIGD1C. Each is linked with COL4A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL4A5-to-partner and partner-to-COL4A5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A5→partner) and Y-score (partner→COL4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ETDB →	+0.048	+2.678	<.001	.002	3	3
LARGE_INTESTINE	ENPP5 →	+0.710	+1.850	.002	.006	3	3
KIDNEY	HIGD1C →	+0.126	+5.000	<.001	.005	3	2
LUNG_SCLC	C9orf92 →	+0.414	+4.523	.001	.003	3	2
LUNG_SCLC	CCL16 →	+0.035	+5.169	<.001	<.001	3	2
SKIN	CCDC179 →	+0.064	+3.519	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 689 associations by consensus.

Exploration

COL4A5 survival (RNA) · tumor vs normal (RNA) · all COL4A5 data types