COL4A4

Across TCGA pan-cancer cohorts, COL4A4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COL4A4 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher COL4A4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COL4A4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THCA, OV, and BLCA are the cancer types where COL4A4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.098	0.941	<.001	42	view →
OV	DFS	Median	II,III,IV	0.292	0.542	.027	18	view →
BLCA	OS	Median	IV	0.246	0.597	.004	15	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	12	view →
SARC	DFS	Median	All	0.185	0.614	.007	6	view →
COAD	OS	Median	III,IV	0.265	0.699	.020	6	view →
UCEC	DFS	Median	All	0.869	0.614	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COL4A4–THCA (OS)

Open the THCA breakdown →