COL4A4

Across TCGA pan-cancer cohorts, COL4A4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COL4A4 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COL4A4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COL4A4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where COL4A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.433	0.869	.001	46	view →
CCRCC	DFS	Quartile	II,III,IV	0.578	0.944	.002	27	view →
LSCC	DFS	Median	All	0.870	0.712	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COL4A4–LUAD (OS)

Open the LUAD breakdown →