COL4A4

Across TCGA patient cohorts, COL4A4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,579 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COL4A4-associated genes across cancer lineages are TNNC1, OR5P2, and OVCH2. Each is linked with COL4A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL4A4-to-partner and partner-to-COL4A4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COL4A4 versus TNNC1 in LSCC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A4→partner) and Y-score (partner→COL4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNNC1 →	+0.882	+0.428	<.001	<.001	3	3
LSCC	OR5P2 →	+0.756	+0.353	<.001	.005	3	3
LSCC	OVCH2 →	+0.859	+0.391	.001	.002	3	3
LSCC	INMT →	+0.989	+0.366	<.001	<.001	3	3
LSCC	MFNG →	+0.425	+0.322	<.001	<.001	3	2
LSCC	RASSF2 →	+0.512	+0.440	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,579 associations by consensus.

COL4A4 vs TNNC1 — LSCC

Explore this scatter interactively →