COL4A4

Across TCGA patient cohorts, COL4A4 mutation is significantly associated with the RNA expression of many other genes, with 5,433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A4-associated genes across cancer lineages are ENPP2, RAD51, and CMC2. Each is linked with COL4A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL4A4-to-partner and partner-to-COL4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP2 grouped by COL4A4-low versus COL4A4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A4→partner) and Y-score (partner→COL4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ENPP2 →	-0.785	-3.807	.003	<.001	3	5
UCEC	RAD51 →	+0.594	+1.477	<.001	<.001	3	5
UCEC	CMC2 →	+0.354	+1.584	<.001	<.001	3	5
UCEC	BNIP1 →	+0.262	+1.353	<.001	<.001	3	5
UCEC	BIRC5 →	+0.422	+1.276	.006	<.001	3	5
UCEC	GTF2E2 →	+0.286	+1.364	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,433 associations by consensus.

ENPP2 by COL4A4 expression — LUAD

Explore this box plot interactively →