COL4A4

Across TCGA patient cohorts, COL4A4 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A4-associated genes across cancer lineages are Caveolin-1, PCNA, and Cyclin-B1. Each is linked with COL4A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A4-to-partner and partner-to-COL4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by COL4A4-low versus COL4A4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A4→partner) and Y-score (partner→COL4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.931	-3.000	.008	.033	3	4
BRCA	PCNA →	+0.183	+3.184	.039	.010	3	4
BRCA	Cyclin-B1 →	+0.603	+3.000	.018	.037	3	3
COAD	eEF2 →	+0.281	+2.204	.010	.031	3	3
SKCM	MYH11 →	-0.456	-0.912	.019	.023	3	3
UCEC	Caspase-8 →	-0.215	-2.073	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Caveolin-1 by COL4A4 expression — STAD

Explore this box plot interactively →