COL4A4

Across TCGA cell cohorts, COL4A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,576 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible COL4A4-associated GO terms across cancer lineages are Glomerular basement membrane development, Regulation of syncytium formation by plasma membrane fusion, and Negative regulation of myoblast fusion. Each is linked with COL4A4 in more than 8 cancer types. Because this analysis shows association rather than direction, both COL4A4-to-partner and partner-to-COL4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glomerular basement membrane development grouped by COL4A4-low versus COL4A4-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A4→partner) and Y-score (partner→COL4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Glomerular basement membrane development →	-0.370	-1.265	<.001	<.001	3	9
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.061	+0.856	.006	<.001	3	8
SKIN	Negative regulation of myoblast fusion →	+0.099	+0.932	<.001	<.001	3	8
KIDNEY	Cytoplasmic translation →	+0.059	+1.048	.002	.001	3	8
LIVER	Macroautophagy →	+0.056	+1.181	<.001	.007	3	7
SKIN	Regulation of myoblast fusion →	+0.044	+0.540	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,576 associations by consensus.

Glomerular basement membrane development by COL4A4 expression — CNS

Explore this box plot interactively →