COL4A4

Across TCGA cell cohorts, COL4A4 mutation is significantly associated with the RNA expression of many other genes, with 1,032 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A4-associated genes across cancer lineages are C9orf92, CFHR2, and TMIGD1. Each is linked with COL4A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL4A4-to-partner and partner-to-COL4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by COL4A4-low versus COL4A4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A4→partner) and Y-score (partner→COL4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C9orf92 →	+0.197	+5.000	<.001	.006	3	3
BONE	CFHR2 →	+0.045	+4.169	<.001	.008	3	2
LUNG_SCLC	TMIGD1 →	+0.088	+5.029	<.001	.006	3	2
KIDNEY	PRR32 →	+0.013	+5.000	<.001	.005	3	2
CNS	OR8G5 →	+0.178	+3.449	<.001	.004	3	2
LARGE_INTESTINE	MAPK8 →	+0.878	+3.800	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,032 associations by consensus.

C9orf92 by COL4A4 expression — PANCREAS

Explore this box plot interactively →