COL4A3

Across TCGA pan-cancer cohorts, COL4A3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COL4A3 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COL4A3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL4A3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where COL4A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.806	0.976	.006	9	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	4	view →
HNSC	OS	Tertile	II,III,IV	0.566	0.862	.016	3	view →
CCRCC	OS	Quartile	II,III,IV	0.825	0.927	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COL4A3–LUAD (DFS)

Open the LUAD breakdown →