COL4A2

Across TCGA patient cohorts, COL4A2 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COL4A2-associated genes across cancer lineages are Caspase-7-cleavedD198, PDK1_pS241, and c-Met_pY1235. Each is linked with COL4A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A2-to-partner and partner-to-COL4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COL4A2-low versus COL4A2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A2→partner) and Y-score (partner→COL4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.392	+3.338	<.001	.004	3	4
LUSC	PDK1_pS241 →	-0.178	-2.321	.001	.033	3	3
LUSC	c-Met_pY1235 →	+0.079	+2.197	.013	.032	3	3
LUAD	GAPDH →	+0.464	+2.584	.035	.010	3	3
COAD	PCNA →	+0.351	+3.915	<.001	<.001	3	3
UCEC	Beclin →	+0.054	+1.273	.041	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caspase-7-cleavedD198 by COL4A2 expression — COAD

Explore this box plot interactively →