COL4A2

Across TCGA cell cohorts, COL4A2 mutation is significantly associated with the RNA expression of many other genes, with 1,166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A2-associated genes across cancer lineages are METTL21A, INTS10, and MMACHC. Each is linked with COL4A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A2-to-partner and partner-to-COL4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL21A grouped by COL4A2-low versus COL4A2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A2→partner) and Y-score (partner→COL4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	METTL21A →	+0.452	+2.743	.002	.001	3	4
LARGE_INTESTINE	INTS10 →	+0.559	+1.949	.002	.002	3	3
LARGE_INTESTINE	MMACHC →	+0.706	+3.130	<.001	<.001	3	3
LARGE_INTESTINE	APTX →	+0.331	+3.252	.001	.002	3	3
LARGE_INTESTINE	OXSM →	+0.560	+2.458	.001	<.001	3	3
LARGE_INTESTINE	FUT10 →	+0.608	+1.949	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,166 associations by consensus.

METTL21A by COL4A2 expression — SKIN

Explore this box plot interactively →