COL4A2

Across TCGA cell cohorts, COL4A2 mutation is significantly associated with the mutation status of many other genes, with 4,169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A2-associated genes across cancer lineages are CACNA1I, MDN1, and ROBO1. Each is linked with COL4A2 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL4A2-to-partner and partner-to-COL4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1I grouped by COL4A2-low versus COL4A2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A2→partner) and Y-score (partner→COL4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CACNA1I →	+2.985	+3.562	.008	.008	1	7
BLOOD_Lymphoma	MDN1 →	+2.510	+3.502	.004	.004	1	6
STOMACH	ROBO1 →	+4.209	+3.000	.002	.002	1	6
URINARY_TRACT	BICRA →	+4.307	+3.672	.004	.004	1	5
SKIN	EPHA6 →	+2.637	+2.206	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	ST18 →	+4.392	+4.954	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,169 associations by consensus.

CACNA1I by COL4A2 expression — LUNG_SCLC

Explore this box plot interactively →