Across TCGA pan-cancer cohorts, COL4A1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COL4A1 data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher COL4A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COL4A1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

THYM, BLCA, and HNSC are the cancer types where COL4A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
BLCA	DFS	Median	III,IV	0.094	0.489	.005	9	view →
HNSC	DFS	Median	III,IV	0.135	0.596	.002	6	view →
STAD	DFS	Median	All	0.800	0.379	.023	5	view →
UCEC	DFS	Median	All	0.887	0.616	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: COL4A1 tumor-vs-normal RNA expression · all COL4A1 data types