Across TCGA pan-cancer cohorts, COL4A1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COL4A1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COL4A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COL4A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where COL4A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.747	1.000	.002	33	view →
PDAC	DFS	Tertile	II,III,IV	0.154	0.452	.010	10	view →
CCRCC	OS	Tertile	All	0.970	0.824	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: COL4A1 tumor-vs-normal RNA expression · all COL4A1 data types