Across TCGA patient cohorts, COL4A1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,122 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible COL4A1-associated genes across cancer lineages are MYCT1, CD93, and COX4I2. Each is linked with COL4A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL4A1-to-partner and partner-to-COL4A1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A1→partner) and Y-score (partner→COL4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYCT1 →	+0.739	+0.321	<.001	<.001	3	7
LUAD	CD93 →	+0.825	+0.334	<.001	<.001	3	7
UCEC	COX4I2 →	+0.919	+0.295	<.001	.007	3	7
BRCA	LRRC32 →	+1.314	+0.628	<.001	<.001	3	7
OV	DIPK2B →	+0.858	+0.675	<.001	<.001	3	7
HNSC	BCL6B →	+0.738	+0.335	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,122 associations by consensus.

Exploration

COL4A1 survival (RNA) · tumor vs normal (RNA) · all COL4A1 data types