Across TCGA patient cohorts, COL4A1 mutation is significantly associated with the RNA expression of many other genes, with 5,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A1-associated genes across cancer lineages are HJURP, FAM136A, and C4orf46. Each is linked with COL4A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL4A1-to-partner and partner-to-COL4A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A1→partner) and Y-score (partner→COL4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HJURP →	+0.634	+1.807	.005	.004	3	5
UCEC	FAM136A →	+0.307	+1.843	.001	.001	3	4
UCEC	C4orf46 →	+0.499	+2.102	<.001	<.001	3	4
SKCM	ITPK1 →	+0.368	+1.309	.001	.002	3	4
COAD	ECT2 →	+0.513	+2.611	.002	.005	3	4
UCEC	KIF23 →	+0.633	+2.091	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,350 associations by consensus.

Exploration

COL4A1 survival (RNA) · tumor vs normal (RNA) · all COL4A1 data types