Across TCGA patient cohorts, COL4A1 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A1-associated genes across cancer lineages are PCNA, c-Kit, and PAI-1. Each is linked with COL4A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A1-to-partner and partner-to-COL4A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A1→partner) and Y-score (partner→COL4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.261	+2.906	.017	.001	3	4
SKCM	c-Kit →	-0.362	-1.362	.039	.028	3	4
LUAD	PAI-1 →	+0.608	+2.584	.011	.010	3	3
STAD	Caveolin-1 →	-0.742	-1.700	.010	.042	3	3
UCEC	Cyclin-B1 →	+0.554	+2.169	<.001	.002	3	3
UCEC	MEK1 →	+0.392	+3.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

COL4A1 survival (RNA) · tumor vs normal (RNA) · all COL4A1 data types