Across TCGA cell cohorts, COL4A1 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A1-associated genes across cancer lineages are CDCP2, FHL5, and FAM47A. Each is linked with COL4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL4A1-to-partner and partner-to-COL4A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A1→partner) and Y-score (partner→COL4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CDCP2 →	+0.012	+2.453	.001	.001	3	2
BREAST	FHL5 →	+0.062	+3.727	<.001	.002	3	2
BLOOD_Lymphoma	FAM47A →	+0.010	+3.130	<.001	.006	3	2
URINARY_TRACT	IL17F →	+0.042	+4.087	<.001	.009	3	1
BLOOD_Myeloma	DEFB124 →	+0.049	+3.285	.002	.009	3	1
BLOOD_Myeloma	GDF5-AS1 →	+0.011	+3.285	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

Exploration

COL4A1 survival (RNA) · tumor vs normal (RNA) · all COL4A1 data types